Collagen Peptides Enhance Cell Proliferation, Promoting Hair Growth
Hair-Growth-Promoting Effects of Fish Collagen Peptides in Human Dermal Papilla Cells and Mice
Su Bin Hwang, Hyeon Ju Park, Bog-Hieu Lee
Epub 2022 Oct 7
Summary:
This study evaluated the effects of fish collagen peptides (CPs) derived from Mozambique tilapia scales on hair growth using human dermal papilla cells (hDPCs) and C57BL/6 mice. CPs were administered orally to mice, divided into four groups: negative control, positive control (finasteride), CP500 (500 mg/kg of CP), and CP1000 (1000 mg/kg of CP). Hair growth measurements and gene expression analysis were conducted.
Results showed that CPs significantly enhanced hair regrowth and the proliferation of hDPCs. The CP1000 group achieved hair growth similar to the finasteride group. CP treatment increased the expression of hair growth-promoting factors (IGF-1, VEGF, Krt27, Gprc5d, Ki67) and decreased the hair growth inhibitory factor (TGF-β1). Additionally, CP upregulated the Wnt/β-catenin signaling pathways and downregulated the BMP pathways.
The study suggests that oral administration of fish-derived collagen peptides can effectively promote hair growth by enhancing cell proliferation, increasing hair follicle size, and modulating key hair growth signaling pathways.